Off-label use of rituximab in refractory pediatric rheumatic diseases: a single-center experience

نویسندگان

  • Francisca Aguiar
  • Joana Abelha-Aleixo
  • Mariana Rodrigues
  • Iva Brito
چکیده

Introduction Rituximab (RTX) is a chimeric monoclonal antibody directed against the CD20 antigen on the surface of B lymphocytes. It binds to CD20 and causes B cells death by different mechanisms. In what concerns rheumatic diseases, it is only approved for the treatment of rheumatoid arthritis. However, there is growing evidence of its utility in other diseases, including in pediatric patients.

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عنوان ژورنال:

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2014